Targetmol

Odporúčaná knižnica fragmentov

Odporúčaná knižnica fragmentov

Objavovanie liečiv na základe fragmentov (FBDD) sa v poslednom desaťročí stalo účinným nástrojom na objavovanie nových liečiv. FBDD zohrala úlohu pri objavovaní najmenej 30 liekov, ktoré sú v rôznych štádiách klinického vývoja, a praktikov FBDD možno nájsť na celom svete v akademickom aj priemyselnom prostredí. Na rozdiel od HTS sa pri FBDD hľadajú hity podobné fragmentom (molekulová hmotnosť nižšia ako 300), ktoré sa zvyčajne viažu s nízkou afinitou; preto sú potrebné citlivé metódy detekcie, ako napríkl

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Knižnica fragmentov s vysokou rozpustnosťou

Knižnica fragmentov s vysokou rozpustnosťou

Knižnica fragmentov TargetMol's Fragment Library Plus zhromažďuje 2731 fragmentom podobných malých molekúl, ktoré spĺňajú prísne Astexovo pravidlo troch kritérií (MW≤300, cLogP≤3, donory väzieb H≤3 akceptory väzieb H≤3) na objavovanie liečiv na báze fragmentov.

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Adrenergic library

Adrenergic library

Adrenergic Library contains 129 kinds of compounds, which target for adrenergic receptor specifically and are used for drug screening.

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Tyrosine kinase inhibitors library

Tyrosine kinase inhibitors library

Contains 159 compounds correspondingly, which is used to research related diseases and drug screening.

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Selected plant source compound library

Selected plant source compound library

A unique collection of Selected plant-sourced compounds including 333 products that derived from 165 plant species.

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Protease inhibitor library

Protease inhibitor library

Contains 69 small molecule inhibitors related with protease and proteasome, for scientific research and drug screening.

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Natural compound library

Natural compound library

Contains more than 730 compounds in natural compound library, from the nature of biological separation, extraction of organic compounds in the body.

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Oxidation-reduction library

Oxidation-reduction library

Contains 71 bioactive compounds aliquoted to 96-well plates, ideal for screening or identifying mechanism research.

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Kinase inhibitors library

Kinase inhibitors library

Contains 481 kinds of kinase inhibitors, targeted for specific protein kinase for high-throughput screening and high content screening.

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Ion channel inhibitor library

Ion channel inhibitor library

Contains 263 small molecule inhibitors related with ion channel, which can be used for high throughput screening and high content screening.

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Inhibitor library

Inhibitor library

Contains over 2,700 active compounds,which can be used in not only specific research but also high-throughput screening and high-content screening.

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Human endogenous ligand library

Human endogenous ligand library

Contains 132 Human-Endogenous-Ligand-Librarycompounds related with endogenous metabolism, which is used for the study of endogenous metabolic diseases and new drug screening.

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Histamine & melatonine library

Histamine & melatonine library

Contains 93 bioactive compounds, ideal for screening and neurodegenerative diseases’ mechanism research.

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Hematopoietic toxicity library

Hematopoietic toxicity library

A focused collection of 104 compounds with defined and diverse hematopoietic toxicity, including myelosuppression, neutropenia, leukopenia, anemia, and many more.

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GPCR compound library

GPCR compound library

Contains 356 active compounds related with G protein and G protein coupled receptors, used for GPCR targeted drug research and drug screening.

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